I've done consulting at a number of client sites where the Alteryx Designer method of using IE proxy server settings isn't suitable. Many enterprises are using automatic configuration scripts for the proxy server settings and this doesn't work with Alteryx Designer. It is often not possible to explicitly set IE proxy server settings in an enterprise environment or in cases where it is possible those settings often revert back each night when group policies are synchronised.
Ideally Alteryx Designer would be able to use automatic configuration scripts or have seperate proxy server configuration that can be configured in the application and not rely on settings in Internet Explorer or Windows.