In case you missed the announcement: The Alteryx One Fall Release is here! Learn more about the new features and capabilities
here
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I first filtered out the nulls and used "Dynamic Rename" to take the column name from the first row of data. I then replaced the non-alpha-numeric characters and replaced them with letter combinations. I then cross-tabbed the data with the appropriate grouping and used the dynamic rename tool to reverse the previous character replacement. Simple.