Please marks as an acceptable solution and like, if this works for you.
Looks like you might need some pre-steps before the Reporting Tools.
1. Summarize: Group by Employee, Group by Region, Sum Sales as Total_Sales
2. Cross Tab: Group by Employee, Column Headers = Region, Values for New Columns = Total_Sales, Method = Sum
And then, you can add the Reporting Tools (in this case, Table configured to Pivot per below)
**You can also check out the basic table examples in Alteryx (click on the basic table, then click on Open Example) to try the other pivoting styles and see which one works for you 🙂