After taking a break from Alteryx, this challenge really threw me back in the deep end. I got a solution but it was wrong so I had to check with the actual solution. I had one filter wrong. && instead of ||. It's good to be using Alteryx again.
Built the solution dynamically so as new measures and/or new brands and/or new weeks and/or new holding companies are added, the program will handle it automatically (assuming the general format of the spreadsheet remains the same).