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What @GarthMiles has provided you with is a great solution, however I will offer an alternative!
I would consider creating a excel/csv file which contains the detail of the vendors you wish to remove. Then you can input this source onto your canvas and perform a join.
Lets say your data stream is the left input to your join tool and your list (as in the excel file I suggested you create), is the right side of the join, then the stream you should take to output would be from the left side of your join.
The reason I would perhaps suggest doing this over using a filter tool is that it is easier to maintain and gives greater visibility over those exclusions to those who do not use Alteryx.