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If Windows 10 patches are not up to date on a machine, opening an Excel binary file (.XLSB) in an Input Data Tool crashes Alteryx Designer.
Microsoft Excel binary files (.XLSB)
Input Data Tool
Windows 10 updates have not been installed. As an additional consideration, if you are unable to see .XLSB as an option in the "File Format" dropdown of the Input Data Tool, you will need to install the Microsoft Access Database Engine 2010 Redistributable (32-bit) as well, found here: