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Right now it is not possible to open .xlsx files in Alteryx that has restricted access to specific users from the excel file, even when you are logged in to Alteryx and Excel with the same user. If it is possible to make Alteryx recognize which users/email addresses should be able to input a file to Alteryx I think it would be a great enhancement. To get around the problem we are currently changing the file restrictions through right clicking on it -> Properties -> Security, but this is time consuming and not a smooth fix.