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Hi @avidey, if I understand your objective, you can achieve this using the Python tool in Alteryx which has an embedded Jupyter notebook inside it.
The Python tool will read data from excel upstream (i.e. you use Alteryx's regular Input tool to read excel data and pass it into the Python tool) as a DataFrame, you apply your relevant Python logic to this DataFrame, and finally, pass it back into Alteryx downstream as a DataFrame.