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I have a hypothesis about this. It's possible that when Office 365 installs, it needs the Microsoft Access Database Engine Redistributable 2016. I know from testing that one cannot install the 2016 redistributable if the 2010 is installed, and It's possible that Microsoft goes ahead and removes the Microsoft Access Database Engine Redistributable 2010 32-bit rendering Alteryx incapable of reading or writing Excel and Access files/databases.
I also know from testing that if the Microsoft Access Database Engine Redistributable 2016 64-bit is installed already, it is possible (at least on the machines I've tested) to install the Microsoft Access Database Engine Redistributable 2010 32-bit, and have both engine drivers installed.
So, although I don't know for sure that this will help, I think it's definitely worthwhile to try these steps:
Uninstall the 2016 32-bit if you have it,
Install the 2016 64-bit if you need a 2016 driver, and then