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We have been working with Alteryx Designer for a few months now and we were never able to interact with the system settings. I would open it, everything was greyed out, clicking next, back, and cancel did nothing, but was only able to close the window by using X. Support suggested many different things to try, but we never got it to work (Uninstall and Disable other antivirus, disable firewall, run Alteryx as Admin, trying a different conf.js file, using process monitor to log the events, open public_html file in IE, and verify scripting was enabled in IE).