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I am relatively new to Alteryx as well but here are my 2 cents. We also use Amazon Redshift and the performance has been descent when i connect it with Alteryx. I use the ODBC connector to read from Redshift and the read performance is as good as what I would get in a live query against that database.
The writes however are very very slow (I think that is due to ODBC or something) and as a workaround I output my data into CSV and then use COPY command to populate my redsfhit tables. We also deal with large amounts of data so give this a shot and probaby it works out for you.